Genes of interest (HGNC Gene Symbol):
Maps of interest
Notes : 1. all interactions from selected maps are shown
2. Expression values are normalized across periods and regions
3. Confidence reflects the probability of each interaction to be binary
(3 - high condidence, 2 - good confidence, 1 - low confidence)
Brain region (show):
R1: Parietal, visual, auditory and temporal cortexR2: Somatosensory, motor and prefrontal cortex
R3: Striatum, hippocampus and amygdala
R4: Thalamus and cerebellum
Developmental period (show):
P2: 13 to 18 PCW
P3: 19 to 23 PCW
P4: 24 to 37 PCW
P6: 1 to 11 Y
P7: 12 to 19 Y
P8: 20 to 40 Y
Node COLOR
Low High expression
Node SHAPE
Autism-risk genes:
Triangle: TADA (List Download)
Star: Class I-II (List Download)
Triangle down: Class III (List Download)
Square: Class SFARI (List Download)
EDGE WEIGHT
Confidence 1 to 3
MY RESEARCH INVOLVES DEVELOPPING INNOVATIVE AND SYSTEMATIC
Computational approaches to analyze genomics and proteomics data of increasing quantity and quality. My goal is to characterize the mechanisms by which genomes, proteomes and interactomes evolve and how their perturbation can lead to different cellular states. In Prof. Bourgeron’s lab, I study the human protein interaction network to characterize complex genotype-phenotype relationships in the context of autism spectrum disorders.
References
Protein-protein interaction maps
- Systematic Y2H (Yeast Two-Hybrid):
- Literature curation:
-
Systematic co-fractionation:
- (Co-fractionation followed by Mass Spectrometry)
Havugimana et al. Cell 2012
- (Co-fractionation followed by Mass Spectrometry)
-
TAP-MS:
- (Tandem Affinity Purification followed by Mass Spectrometry)
Huttlin et al. Cell 2015
- (Tandem Affinity Purification followed by Mass Spectrometry)
- Systematic prediction:
Spatio-temporal expression
- Exon transcriptome from:
- Quality control and normalisation as in:
- Brain regions and developmental periods from:
Autism-risk genes
- TADA genes from:
- Class I, II and III genes from:
- SFARI genes from:
